Injury patterns in
COVID-19 lungs
Perivascular Inflammatiion
We showed clotted blood vessels with a pronounced inflammation around the smaller blood vessels.
We identified the inflammatory infiltrate to consist predominantly of T-cells: CD3 (white), CD4 (green), CD8 (yellow), CD20 (purple), CD68 (red) and cell nuclear stain (blue).
Lung alveoli with hyaline membranes and new blood vessels
Covid-19 lungs showed showed a characteristic formation of eosinophilic hyaline membranes (arrows) superimposed on the mildly edematous alveolar walls and new blood vessel formation (angiogenesis).
Aberrant angiogenesis
COVID19-lungs showed an aberrant angiogenesis with a high occurence of intussusceptive angiogenesis and partly vascular disruption.
Intussusception
Intussusceptive angiogenesis was identified via the occurrence of tiny holes with a diameter of 2-5 μm. Microvascular alterations by intussusceptive angiogenesis may contribute as one of the pivotal pathogenetic mechanisms in the progression of disease of COVID-19.
© 2020 Maximilian Ackermann. All rights preserved.
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